Fertility age – Age is the single most important factor affecting female fertility and her chances of having a child. Women are born with all the eggs they will ever have, as she ages her eggs age with her diminishing in quantity and quality fertility and fecundity decreases with increasing age.
Statistical figures about female, age and fertility
Starting at about age 32, a woman’s chances of conceiving decreases gradually but significantly.
- From age 35, fertility chances taken by half.
- At 30, chances of conceiving per month is about 20% which declined to about 5% by the age of 40.
Infertility treatment cannot fully compensate for decline in fertility by age. Women undergoing IVF using their own eggs demonstrate that the drop in IVF success is also dramatic. For women under 35 years, the percentage of successful IVF cycles is 41%, for women 35-37 years was 31.9%, between 38-40 years was 22.1%, 12.4% for woman 41-42years, 5% for women 42-44 years and just 1% for women over 44%. That means, after 35 years, IVF birth declined about 10% every 2 years reflecting on similar relationship between fertility and age as we see in natural fertility.
Ovarian reserve and age
Ovarian reserve declines with age. Women normally born with 1-2 million potential eggs (ovarian follicles). Ovarian reserve is like a “bank” that does not take deposits and we are constantly withdrawing from it with each passing month. At puberty – there will be around 1 million eggs which decline to 3,00,000 by 25 years and as the women reaches 35 years the decline starts to get steeper until menopause.
Assessment of ovarian reserve
- Antral follicle count – by ultrasound to count number of visible follicles.
- Antimullerian hormone
- Protein secreted by granulose cells of the preantral and antral follicles.
- Estimate the total number of follicles inside the ovary.
- Value remain stable throughout the cycle.
Depending on the age, the values will be higher or lower.
Miscarriage and age factor
As the women gets older the incidence of chromosomally abnormal eggs increases dramatically. The mecoha spindle is a critical component of eggs that is involved in organising the chromosome pair so that proper dunsion of pairs occurs as the egg is developing. The older eggs have significantly more abnormal spindles redisposing to development of chromosomally abnormal eggs. Dneuploid eggs and embryos are responsible for most of the decline in fertility with female aging and for the low pregnancy success rates with IVF and increased miscarriages for women over 40 years of age. The real issue is egg quantity and quality which translates into embryo quality after fertihydration. It is high time that the couples be made aware that medical science still cannot undo the effects of aging.
Statistics say that about eighty percent of the couple that approach for infertility treatment can be treated by counselling alone and it is only twenty percent of them that require some form of infertility treatment.
Infertility is not a disease but a condition where in a particular couple is not able to conceive. Infertility problems in a couple can be due to either the woman or the man, or it can be even due to problems in both ….
Infertility diagnosis is performed initially, by collecting complete medical history and physical examination. It will then followed by diagnostic tests for infertility. The common tests are urine tests, blood tests, …….
As the age increases the ovarian reserve (total no of eggs) in the ovary will significantly come down (especially after 33 years) and there seems to be issues in women like fibroid, endometriosis etc which ……
IVF Treatment Procedures
IVF (Invitro Fertilisation) refers to a procedure where women’s egg are removed and fertilized with man’s sperm outside the body in the laboratory. The embryos thus formed are then put back into the uterus ….
Intra Uterine Insemination
IUI and AI are one and the same fertility treatment. A small tube is used to place specially washed sperm directly into the uterus. While fertility drugs are not always used during IUI, most doctors ……
While every fertility clinic’s IVF protocol will be slightly different and IVF treatment are adjusted for a couple’s individual needs, here is a step-by-step breakdown of what generally takes place during an ……
With ovarian hyperstimulation syndrome (OHSS), though, the ovaries become dangerously enlarged with fluid. This fluid can leak in to the belly and chest area, leading to complications. If your doctor …..
Female infertility include problems with ovulation, damage to fallopian tubes or uterus or problems with cervix. Age is another major issue that contribute to infertility because when a women ages, her fertility …….
The objective of the fertility treatment is optimization of outcome with minimization is opting of risk. A flexible dosing during stimulation is essential for optimizing the cycle outcome.
Ovulation analysis is the process by which the fertility is assessed to find the fertile window and general assessment. Various methods exist for ovulation testing. Various methods exist for ovulation testing.
It is used to know whether the fallopian tubes of the patient are blocked and whether blockage is at the junction of tube of uterus (proximal) or at the distal end. Radiographic contrast dye is …….
Cryopreserving agents that minimize damage to the cells during freezing and thawing process. Semen cryopreservation also called sperm banking is a procedure to preserve sperm cells.
Transvaginal sonography is one of the indispensable investigation as far as infertility patient is concerned. It is non-invasive and the single test that parallels to clinical assessment. Assessing the …..
As the women gets older the incidence of chromosomally abnormal eggs increases dramatically. The mecoha spindle is a critical component of eggs that is involved in organising the chromosome ….
All the macroscopic parameters in semen analysis, denote the functional capacity of the necessary male organs namely seminal vesicles, prostate and whether or if the whole tract from testes to the …..
In general, semen analysis, hysterosalpingogram, assessment of ovulation and ovarian reserve should be the initial investigations and if no cause of infertility found, laparoscopy should be done.
Anything that effect the hypothalamus pituitary endocrine system which regulates the sperm production can be detrimental. There are also a wide variety of physical problems like varicocele, ……
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